& Audhya, T
activation of Nrf2, the cellular protective pathway
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With a variety of metal ions that could bind competitively with the chelator (e.g., calcium, magnesium, zinc, copper, manganese, and other metals, that typically exceed concentrations of toxic elements), the identity of the metal predominately bound by a chelating agent depends both upon accessibility of the chelator to the tissues, how strongly the metal is already bound in the tissues, how strongly the metal binds to the chelator, and to some extent the relative quantities of various ions [1]
High mobility group box-1 release from H 2 O 2 -injured hepatocytes due to sirt1 functional inhibition
