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Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A et al

Current and Future Research Directions Include: Deeper Mechanistic Studies: Unraveling the exact signaling pathways and molecular targets through which MOTS-c exerts its effects, including its interaction with nuclear transcription factors and other cellular components

Increase to 1.5-2mg if effects insufficient

10.1371/journal.pbio.1001051 128

CHE is recognized as an important issue in cirrhosis care [7, 8], and global liver societies recommend routine screening in this population [2,3,4,5,6]