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Ethics declarations Ethical approval and consent to participate The protocol of this study has been permitted by the Research Ethics Committee (Faculty of Pharmacy, Cairo University) with approval number PT (2963)

It is produced in specialized cells called melanocytes, primarily found in the epidermisthe outer layer of our skin

PTX is a xanthine derivative that functions as a nonspecific phosphodiesterase inhibitor with known anti-inflammatory and anti-fibrogenic properties (30)

Many people use them together (called the "Wolverine Stack") because they heal through different pathways and amplify each other's effects

Thus, the elimination of the basal flux and low H 2 O 2 levels is performed by GPx and Prx2, since CAT does not work efficiently at low H 2 O 2 levels [60]