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Choose 2mL (5mg/mL) if: You are starting retatrutide for the first time Your current dose is 5mg per week or lower You want maximum measurement accuracy You prefer straightforward math Choose 1mL (10mg/mL) if: Your dose is 6mg per week or higher You want smaller injection volumes You are comfortable with precise syringe measurements You have experience reconstituting peptides Some researchers start with 2mL during their initial escalation phase and switch to 1mL once they reach maintenance doses above 4mg

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Our guide on what to do when tirzepatide stops working and troubleshooting stalled weight loss covers these scenarios in detail