Shared Effects Both medications can reduce appetite, increase fullness, and slow digestion
If needle aversion is the primary barrier to semaglutide, the oral formulation removes that obstacle
Mechanisms of Tirzepatide: GLP-1 receptors GIP receptors This dual action produces powerful effects on appetite regulation, insulin sensitivity, blood sugar control, and energy balance
Jump to: What to expect when switching | Weight loss comparison | How to switch safely | Take home message You can switch from Wegovy (semaglutide) to Mounjaro (tirzepatide) under medical supervision, though youll need to start at a lower dose of Mounjaro and gradually increase it
Patients should be seen or contacted within 2-4 weeks of initiation to assess tolerability, review lifestyle adherence, and address concerns