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[1] [2] The discovery of exendin-4 in the 1990s revolutionised diabetes treatment by demonstrating that GLP-1 receptor agonism could effectively lower blood glucose levels whilst promoting weight loss

Based on trial data published to date, the known adverse effect profile of retatrutide includes nausea, vomiting, diarrhoea, decreased appetite, injection site reactions, and increases in resting heart rate

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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Colloca L., Ludman T., Bouhassira D., Baron R., Dickenson A.H., Yarnitsky D., Freeman R., Truini A., Attal N., Finnerup N.B., et al