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doi:10.1016/j.freeradbiomed.2013.05.019, PMID: 23707456 Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2011) Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis/chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression

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Oral glutathione supplements are largely broken down in the digestive tract, significantly reducing the amount that actually reaches your bloodstream