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After supplementation this between-group difference disappeared: post-intervention LDL no longer triggeredand sometimes inhibitedIL-1beta release, even though plasma apoB itself was unchanged

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To validate our candidate variants and test the effect of the P72R SNP, we cloned each of our 5 variants, C141Y, T155I, G245C, G266V, and P278R, into doxycycline-inducible vectors containing either the P72 or R72 SNP