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Interventional strategies for ischemic stroke based on the modulation of the gut microbiota

Group A: Received a daily dose of 500mg of liposomal glutathione for seven consecutive days

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Gutbloodbrain axis disruption: Dysbiosis affects communication along the gutbrain axis, increasing intestinal permeability (leaky gut) and allowing microbial toxins like LPS and bacterial amyloids to translocate into systemic circulation, triggering systemic inflammation (Wu et al., 2021)

Furthermore, interventional studies in DSS-colitis suggest targeting ferroptosis could be therapeutic: -caryophyllene inhibition of macrophage lipid peroxidation and ferroptosis was linked to suppression of inflammation [12], and seliciclib-treated micethat displayed reduced epithelial ferroptosishad less severe DSS-induced colitis [41]