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Epub 2009 Oct 27

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Evidence for a gutimmunebrain axis in neurological disorders To date, this review has addressed evidence for gut microbiota-mediated regulation of host immunity, the roles of brain-associated immune cells in health and disease, and various pathways by which commensals influence and are influenced by the brain

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Early-life LPS exposure induce microglial activation and triggers persistent DA neuron loss from infancy through adulthood, with maximal vulnerability observed at embryonic day 10.5a critical developmental window for DA neurogenesis (Zetterstrm et al., 1996)