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A counterfeit Ozempic pen was found in the United States earlier this year, with Novo Nordisk warning that it appeared to contain a different diabetes medication.
Similar to the observation in myocytes, the top predicted ligands for upregulated genes included TGF1 and WNT5b, while predicted ligands for downregulated genes included TGF1 and slc6a8 ( note: different genes in the TGF 1 pathway were enriched amongst down-versus up-regulated genes following semaglutidethis is unsurprising, as cytokines like TGF 1 induce gene suppression as well as activation, and the effects of semaglutide impact both vectors of transcriptional change )
Potential autoimmune effects
Tirzepatide is a dual GLP-1 and GIP receptor agonist, activating two separate hormonal pathways involved in appetite regulation and metabolic function