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Although Italian researchers first developed PDRN in the 1990s for wound healing, Korean clinics advanced its aesthetic use in the early 2000s through skin booster injections associated with the coveted glass-skin effect

doi: 10.1016/j.ijfoodmicro.2021.109104, 170

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The transition from episodic to chronic migraine involves changes in nociceptive thresholds and central sensitization, driven by factors such as high frequency of migraine attacks, overuse of acute medications, obesity, stress, female sex, psychiatric conditions, and low socioeconomic status (34)

Ginseng shows promising potential by targeting multiple pathways, including lipid metabolism, inflammation, oxidative stress, and gut microbiota regulation