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Looking beyond SELECT, which focused on secondary prevention, the ultimate prize is still to be seized primary prevention, a huge potential opportunity

Mechanistically, TQ influences various signaling cascades crucial for cancer progression, such as the PI3K/Akt/mTOR pathway, NF-B pathway, and MAPK pathway (100)

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1 Most clinical guidance focuses on maternal exposure

The prevalence of CYP2D6*4, CYP2D6*10, CYP3A5*3 and CYP2C19*2 allelic variants and their correlation with tamoxifen resistance was intensively investigated