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While some studies have indicated positive changes in mitochondrial function during active treatment, these benefits tend to diminish once treatment is discontinued (Old et al., 2025

Generally, this medication is considered safe

For example, semaglutide can reduce N-terminal pro brain natriuretic peptide (NT proBNP) by 30% in heart failure patients with preserved ejection fraction (HFpEF), and reduce the risk of cardiovascular death and hospitalization due to heart failure by 31%

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doi: 10.1002/edm2.9 132 WernerE.BellJ