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Deficit targets based on STEP 1 (NEJM 2021) and SURMOUNT-1 (NEJM 2022) trial protocols.

In BRAF V600E-mutant CRC, tumor cells often exhibit an initial response to BRAF inhibitors, but frequently develop resistance through reactivation of the MAPK pathway, commonly via KRAS amplification or MEK mutations [76]

That does not make tirzepatide better than CagriSema in a head-to-head sense, because there has been no head-to-head trial

To start, gather basic medical details and complete the eligibility questionnaire so clinicians can triage safely and efficiently