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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the cytosolic enzyme that methylates nicotinamide to 1-methylnicotinamide (1-MNA) using S-adenosyl-L-methionine (SAM) as the methyl donor

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The relative abundance of the [ Eubacterium ] coprostanoligenes group was greater in both the vehicle- and 5A-1MQ-treated groups switched from WD to LD compared to the LD control group (Supplementary Fig