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No large-scale randomised controlled trials have evaluated this combination, and current prescribing guidance from the MHRA, NICE, or EMA does not specifically address concurrent use

10.1016/j.bse.2019.01.001 56 ZhangY.HeJ.XiaoY.ZhangY.LiuY.WanS.et al (2021)

In UK practice, NICE guidance recognises these benefits, though SGLT2 inhibitors are typically prioritised for cardiorenal protection, with GLP-1 receptor agonists with proven cardiovascular benefit considered when SGLT2 inhibitors are unsuitable

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(These are class-level patterns