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This review confirms that pharmaceutical residuesintroduced through manufacturing, consumption, and improper disposalpersist in aquatic and terrestrial ecosystems, with documented effects including endocrine disruption, neurotoxicity, and the propagation of antimicrobial resistance

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doi: 10.1186/s42358-021-00194-4 Summary Keywords cellular transdifferentiation, granuloma, inflammasome, macrophages, neutrophil extracellular traps, sodium urate crystals, tophi Citation Yan H, Yang B, Xiao N, Zhang J, Xu Y, Chen B, Zeng S, Qian H, Zhao S, Wang R, Xie J, Li Z and Xie Z (2026) From uric acid to tophi: multistage molecular and cellular mechanisms of tophi formation

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