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Cell-mediated immunity primarily needs protein antigen degradation in the endocytic vesicles of antigen presenting cells (macrophages, dendritic cells), to be able to present smaller peptides on the cell surface through major histocompatibility complex antigens to activate antigen-specific T cell proliferation

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Patients with -thalassemia have a higher risk of stroke than the general population, which may be due to multiple factors such as iron overload, splenectomy, and hemolysis (101, 197)