Clin Dermatol 27(5):435445 Miyake M, Yamamoto S, Sano O, Fujii M, Kohno K, Ushio S, Iwaki K, Fukuda S (2010) Inhibitory effects of 2-Amino-3 H-phenoxazin-3-one on the melanogenesis of murine B16 melanoma cell line
Zou Y, Sun X, Wang Y, Yan C, Liu Y, Li J, et al
Cell culture and Western blotting The TC1-6 cell line was purchased from ATCC
Glutathione + Laser Toning: Active light energy is used to shatter pigmented granules that are cleared away in the body, and glutathione prevents the formation of pigments
It is reported that high concentrations of fumarate and succinate can enhance the 3-methylation of histones H3K4 and H3K27 by inhibiting KDM5 histone demethylase (responsible for H3K4 demethylation) and JMJD3 histone demethylase, respectively, which in turn promotes the expression of pro-inflammatory cytokine genes (99, 115, 125, 161, 162)