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Food and Drug Administration 2024 2 Drucker DJ Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 Cell Metabolism 27(4) 2018PMID: 29617641 PubMed 3 Bezin J, Gouverneur A, Penichon M, et al

Systemic exposure of each metabolite was less than 10% of total drug-related material

Li Z, Liu H, Luo X

However, N-terminal modifications, such as N-acetylation, D-norleucine substitution, or replacement with -aminobutyric acid (GABA), dramatically elongated the peptides half-lives

2 Indications that may warrant additional assessment and/or laboratory testing prior to therapy: Prior history of a very low-calorie diet, bariatric surgery, celiac disease, other inflammatory conditions predisposing to nutrient deficiency