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found that MAM-resident protein FUNDC2 participated in ferroptosis by regulating mitochondrial GSH levels through the FUNDC2-SLC25A11 axis in doxorubicin-induced cardiomyopathy[60]
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Oh yes, at least 18 months of intensive analysis type work with a very skilled psychiatrist But Andrew wasnt trying to seed the dream He was just at a sticking point with a certain process in his life While he was taking a walk, he realized his brain (his subconscious) was going to keep working on this Then two nights later, he traveled to a meeting in Aspen and had the most profound dream ever He was able to sense something and feel something hes always wanted to feel It was so real within the dream He woke up, knew it was a dream, and realized this is what people close to him that he respects have been talking about He was able to feel it and therefore can access this now in his waking life It was transformative Why Peter chose a paper on metformin, how metformin works, and why it generated excitement as a longevity-enhancing agent [9:00] The paper were going to talk about is pretty straightforward: Reassessing the evidence of a survival advantage in Type 2 diabetes treated with metformin compared with controls without diabetes: a retrospective cohort study By Matthew Thomas Keys and colleagues
The observed upregulation of not only the ThDP-dependent dehydrogenases limiting and feeding the TCA cycle, but also the thiamine transporters and ThDP-producing enzyme TPK1 (Figures 4B, 5B), may compensate for decreased levels and/or increased demands of thiamine in enterocytes 69 months after gastric bypass, facilitated by the higher expression of the proteins binding thiamine or ThDP
