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10.1016/j.cbpb.2021.110706 29 HofsteeP.BarthoL.McKeatingD.HollandO.VanderlelieJ.CuffeJ.et al (2017)

For example, in the 1940s, doctors distinguished between allergic and non-allergic asthma, based on whether an allergen was likely involved in the asthma symptoms or if the asthma seemed to come from within.[ref] Since then, a better understanding of cellular processes and lung tissue has led to better classifications based on biomarkers

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Sex steroids further enhance the function of the GH-IGF-axis, most likely by attenuating pituitary and hypothalamic sensitivity to IGF-I negative feedback (78)