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Looking ahead, the authors point to what the field needs next: models that better combine physiological relevance with reproducibility and scalability, supported by accepted reference compound panels and richer multimodal readouts that can help unlock the potential of machine learning

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It will be interesting to understand the functional consequences of these changes, which are relevant for possible application in the development of GLP-1R agonists for medical application in diabetes treatment and for better understanding of the function of these changes in monotreme GLP-1

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Preferably with meals or as directed by a healthcare professional