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It is generally accepted that excess cytosolic copper is tightly bound by the metallothioneins, preventing the existence of free, unbound copper ions

In the context of wet age-related macular degeneration (AMD), geniposide (GEN), a GLP-1RA, is found to downregulate HB-EGF (heparin-binding epidermal growth factor) secretion from retinal pigment epithelium (RPE) cells under hypoxic conditions through the miR-145-5p/NF-B signaling axis

A cross-sectional study conducted by Artimani et al