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In some embodiments, the otoprotectant is a compound of Formula (XI): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4

Figure 2 Table 1 Overview of published cases of VPA intoxication treated with extracorporeal removal procedures

Human clinical-trial data (Phase 1/2 studies in wound healing, cardiac injury, and dry eye) exist only for a different, full-length recombinant thymosin beta-4 product, not for the short synthetic fragment marketed as TB-500, so no completed published human trial has evaluated TB-500 specifically for muscle, tendon, or joint recovery

Prespecified positive and negative controls To evaluate the validity of our approach, we conducted analyses using both positive and negative outcome and exposure controls

UV rays from the sun, toxins in air pollution, chemicals in cosmetics, even touching our face roughly can damage our delicate skin