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On intensification to basal insulin, differences between the treatment arms were abolished by reverting each parameter to baseline, with per-person-year rates of 4.08 applied for non-severe hypoglycemia and 0.01 applied for severe hypoglycemia, based on data from the UK Hypoglycaemia Study Group [28]

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Efficacy and tolerability of glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus

Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes

When used concurrently with insulin or insulin secretagogues such as sulfonylureas or meglitinides, the risk of hypoglycemia may be increased, particularly during the initiation of therapy or following dose escalations