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Dysbiosis of the microbiome forms a new internal environment, under which it may affect the development of GERD from the perspectives of molecular mechanisms: microbial activation of Toll-like receptors, microbial stimulation of cyclooxygenase-2 expression, microbial stimulation of inducible nitrous oxide synthase, and activation of the NLRP3 inflammatory vesicle
L., Hsu, J
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WB Saunders, Philadelphia, pp 833873 Helivaara M, Knekt P, Aho K et al (1994) Serum antioxidant and risk of rheumatoid arthritis