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Elevated plasma BCAAs were highly correlated with insulin resistance in CVD patients 65 , and predicted the risk of diabetes as well as CVDs 66,67,68,69,70

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Even mild dehydration, losing just 1% to 2% of body water, reduces cognitive performance by 10% to 15% and increases perceived fatigue significantly

The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository (proteomexchange.org) with the data set identifier PXD036803 ( The mass spectrometry metabolomics data (2 data sets from kidney and plasma, respectively) have been deposited to the Zenodo repository ( All reagents, softwares, mouse lines, and data repository information are available in Supplemental Table 7