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Ultimately, after being released into the synaptic space, it is taken up by surrounding neurons and glia, resulting in neurodegeneration ( 4 The role of Sirts in PD Sirtuins (Sirts) are proteins that belong to the nicotinamide adenine dinucleotide (NAD + )-dependent deacetylases family (Histone Deacetylase or HDAC)

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