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Determination of in vitro permeability of drug candidates through a caco-2 cell monolayer by liquid chromatography/tandem mass spectrometry

Technologies such as permeation enhancers, LBFs, and enteric protection have made the oral delivery of biologics a reality

This article aims to provide a comprehensive overview of the role of Gln transporters in DSMTs, along with an exploration of targeted therapeutic drugs, with the goal of providing valuable insights into the drug discovery process for DSMTs therapy and deepening our understanding of the underlying mechanisms