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It is worth noting that recent clinical trials (such as STEP-HFpEF) suggest that despite a reduction in lean body mass, patients physical functioning (such as exercise endurance) may still significantly improve, indicating that we need to reassess the clinical balance between muscle mass decline and functional benefits.In clinical practice, the potential risks of GLP-1RAs cannot be ignored, especially in the elderly and those already suffering from sarcopenia

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Every patient is different, so results will vary