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Zepbound contains tirzepatide, a dual-acting medication that targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

Conversely, thiamin deficiency appears to impair the normal endocrine function of the pancreas and exacerbate hyperglycemia

Patient B: Jennifer, 43 Starting weight: 242 pounds Height: 57 Exercise approach: No resistance training, some walking, protein intake around 50-60g daily After 11 months: Weight: 168 pounds (74 pounds lost) Body fat: 34% (down from 43%) DEXA scan: 47 pounds fat lost, 27 pounds muscle lost Resting metabolic rate: Dropped 280 calories from baseline Clothing size: 22 to 12 Strength: Not assessed (no baseline) Jennifer looked deflated

The medication price and the clinical visit price are separate line items in Amazon's program a distinction that catches some patients off guard when they calculate their actual total monthly spend