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However, oral supplementation of L-arginine, the precursor for NO synthesis, has been shown to be largely ineffective at increasing NO synthesis and/or bioavailability for several reasons, which makes L-citrulline much more ideal for boosting levels of L-arginine and subsequently NO

Li, X., Robinson, S.M., Gupta, A., Saha, K., Jiang, Z., Moyano, D.F., et al., ACS Nano , 2014, vol

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Injection Frequency Patients self-administering frequent injections (e.g., diabetics) benefit from thinner needles to minimize pain and reduce tissue scarring