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These factors may include the strength of the evidence, impact on the persons quality of life, and whether the injury is life-altering

Consistent with these findings, microglia from TREM2-deficient animals under cuprizone-induced demyelination or in models of focal lysolecithin demyelination exhibit failure in their activation, showing less proliferation, resting morphology, lower expression levels of MHC class II and iNOS, deficits in phagocytosis of myelin debris and lipid metabolism (138), persistent demyelination after chronic use of cuprizone, more aggressive reduction of oligodendrocytes and clinical worsening (138, 139)

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We also discovered that the water shutoff valve was located in the middle of Bear Valley Road. City workers closed a portion of Bear Valley Road to access the line, which was turned off