GSH biosynthesis occurs exclusively in the cytosol via a two-step ATP-dependent reaction catalysed sequentially by two enzymes: gamma-glutamylcysteine synthetase (GCL also referred to as gamma-glutamylcysteine ligase, comprising the catalytic GCLC subunit and regulatory GCLM subunit), which catalyses the rate-limiting first step of joining glutamate and cysteine
It targets melanin production, which reduces the appearance of dark spots, age spots, and uneven skin tone
However, there are more things to know about using glutathione for skin brightening
The sociability scores were calculated as: social motivation score = exploration of stranger/(total exploration in phase 1) and social recognition score = exploration of novel rat/(total exploration in phase 2)
Mobli M, Morgenstern D, King GF, Alewood PF, Muttenthaler M