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This comes from both increased calorie burning (higher resting metabolic rate) and enhanced fat mobilization from storage

Dose and duration

Physiological melanin hyperpigmentation is the result of increased melanin biosynthesis by melanocytes in the basal cell layer of the oral epithelium, but pathological melanin pigmentation may be the result of increased number of normal melanocytes or atypical melanocytes, of increased melanogenic activity of normal or atypical melanocytes, or of both

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Bupropion XL 300 mg daily or SR 150 mg twice daily are common adult doses