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J.CleversH.et al (2015)

(258) and Dekant et al

But weekly injections, cost, and insurance complications mean they're not for everyone

In addition, while cholinergic treatment with nicotine significantly suppresses pro-inflammatory cytokine release by macrophages it fails to generate this effect in macrophages from 7nAChR KO mice or macrophages with 7nAChR anti-sense downregulation (Wang et al., 2003)