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Following study selection, data extraction was performed independently by RM and RC using a structured extraction form in Microsoft Excel, with all entries cross-checked for accuracy

No dose-response studies exist examining skin brightening efficacy across different dosage levels

[DOI] [PubMed] [Google Scholar] 92.Humphries F., Shmuel-Galia L., Ketelut-Carneiro N., et al

This entire process prevents the cell from producing misfolded or altered proteins.[ref] Studies show that high homocysteine levels cause ER stress and activate the unfolded protein response pathway, which can lead to cell death

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