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Immunonutrition formulas typically refer to enteral nutrition preparations fortified with specific immunomodulatory nutrients (e.g., arginine, -3 polyunsaturated fatty acids, nucleotides) ( The European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines recommend that patients undergoing major upper gastrointestinal cancer surgery should routinely receive oral immunonutrition for 57 days preoperatively, regardless of their preoperative nutritional status (117)

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