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Risk factors for the development of melanoma include: The risk of melanoma metastasising is highest in an individual with an aggressive rapidly growing melanoma, an unrecognised melanoma, advanced primary melanoma, melanoma that was not completely excised (or not removed at all), and/or is immunosuppressed

While melatonin can help in select cases, the American Academy of Pediatrics does not endorse routine use without a pediatricians guidance