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Since the isolation of the cDNA in 1994, the work on the mammalian Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms MTHFR gene has resulted in significant advances in our understanding of its genomic organization, genetic variations and involvement in human disorders

Combination of BDNF-like, NGF-like, and CNTF-like activities provides broad neuroprotection covering multiple cell types and stress conditions

HGF Modulates Inflammation and Immune Response in the Brain Local or systemic inflammation is a common response after insults such as tissue injuries and leads to secondary damages such as tissue destruction

For instance, Sja -miRNA-7-5p down-regulates the S-phase kinase-associated protein 2 gene [111], Sja -miR-3096 targets phosphoinositide 3-kinase class II alpha (PIK3C2 A) gene [112], Sja -miR-61 induces an anti-angiogenesis activity by targeting the PGAM1 gene [113], and Sja -miR-71a targets the FZD4 gene [114]

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