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Moreover, Lip-1 reduced microglial activation and the secretion of pro-inflammatory cytokines such as IL-6 and TNF-, while mitigating oxidative stress, lipid peroxidation, mitochondrial damage and neuronal injury following LPS exposure

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Patients receiving the placebo showed no improvement

Preclinical studies confirm that combined treatment with HF and an EGFR-TKI exerts synergistic cytotoxicity compared with EGFR-TKI monotherapy, highlighting promising application prospects, especially in overcoming resistance to third-generation EGFR-TKIs ( 6.3 Critical assessment and challenges of SSP-targeted therapy 6.3.1 Target specificity and toxicity evaluation in normal tissues The SSP is not only aberrantly activated in tumor cells but also participates in fundamental metabolism in normal tissues, including the nervous system, immune cells and the liver