Alzheimers disease (AD), the most common form of dementia worldwide 270,271 , is characterized at the molecular level by the accumulation of A plaques, tau neurofibrillary tangles (NFTs), declined NAD + levels, mitochondrial stress, and impaired mitophagy, occurring first in the medial temporal lobe and eventually spreading to temporal and parietal cortices, and cortex 112,242,243,270,271,272
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A double-blind randomized placebo-controlled trial found that amifostine (740 mg/m 2 ) improved the sensory neuropathy induced by platinum/taxane-based treatment of ovarian cancer, but there was almost no difference in specific sensory or motor symptoms of self-estimation [150]
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Validation of these observations has been done experimentally by quantitation of 8-Oxo-2-deoxyguanosine (8-OHdG), a known marker of oxidative stress-mediated damage to DNA 30 in DNA digests from tumor tissues and blood lymphocytes