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Heat stress activates thermoregulatory mechanisms (increased cardiac output, sweating), but uncompensated fluid/electrolyte loss induces mild illnesses (heat syncope, cramps, exhaustion) or severe heat stroke (HS) [3, 4]

When tirzepatide is discontinued, the pharmacological effects that supported weight loss gradually diminish

Rssler AS, Pfaus JG, Kia HK, Bernab J, Alexandre L, Giuliano F

The 4-PBA group showed mild sinusoidal congestion with focal hepatocyte necrosis as manifested by nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia (Figure 8A), yet it significantly attenuated histopathological scoring compared to MTX-group (Figures 8BD)

202 The mechanism may be related to miR-3173-5p in exosomes secreted by CAFs, which is taken up by PDAC cells and inhibits ferroptosis by downregulating ACSL4 expression