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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females

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Second, after the core-H 1 H 2 H 3 probes were incubated into living cells, a target GSH was able to fracture the disulfide bond of H 1 probe via a thioldisulfide exchange reaction

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