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Helbock HJ, Beckman KB, Shigenaga MK, Walter PB, Woodall AA, Yeo HC et al

In clinical studies, high circulating TMAO levels have been associated with increased risk of major adverse cardiovascular events 18 , coronary heart disease 19 , cardiometabolic disease 20 , hypertension 21 , and atherosclerosis 22

Most cases of CHD are caused by the blockage of coronary arteries due to either atherosclerosis, thrombosis, or a combination of both (Ulbricht and Southgate, 1991)

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