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Intracoronary infusion of nor-NOHA (0.1 mg/min) also enhances endothelium-dependent vasorelaxation in coronary arteries in patients (age 69 3) with CAD (n = 16), or CAD and T2D (n = 16), but not in healthy subjects (n = 16) (Shemyakin et al., 2012)

Another natural compound, trigonelline, a methylated form of nicotinic acid, is a newly discovered NAD + precursor able to increase NAD + in multiple species, with preclinical implications for use in sarcopenia, and for muscle and cognitive decline in aging 124,130,131