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Although the study population was selected after matching by age and sex, the identified metabolic signature could be influenced by other sociodemographic factors and clinical variables that are highly related to metabolism, including ethnicity, diet, physical activity and medication use during the 12-month follow-up

National Scientific and Technological Major Special Project for Significant Creation of New drugs (NO.2020ZX09201020)

The quality of included studies was assessed using appropriate tools such as the Cochrane Collaboration's tool for assessing risk of bias in randomized trials or the Newcastle-Ottawa Scale for observational studies

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