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With the caveat that this case series includes only four cases, it appears that narrower optic nerve heads may pose a greater risk for semaglutide-associated NAION, potentially independent of systemic risk factors

In my case and at this small dose of medication, I have not noticed any changes to my usual schedule

The 2025 pilot study showed tirzepatide increased total testosterone, free testosterone, and bioavailable testosterone in obese men with metabolic hypogonadism, outperforming both lifestyle changes alone and testosterone replacement therapy

But it primarily depends on individual treatment plans